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Key Points: NICE draft recommendation for Sofosbuvir

PLEASE NOTE: This is draft guidance; NICE has not yet issued final guidance to the NHS

What is recommended for treatment on the NHS?

Sofosbuvir, interferon and ribavirin for adults with:

  • Genotype 1
  • Genotype 3 with cirrhosis
  • Genotype 3 who have previously tried treatment

Sofosbuvir and ribavirin (without interferon)

  • Genotype 2 who have not tried treatment before and are interferon intolerant or ineligible
  • Genotype 2 who have tried treatment before
  • Genotype 3 with cirrhosis

What is NOT recommended for treatment on the NHS?

Sofosbuvir, interferon and ribavirin for adults with:

  • Genotype 4
  • Genotype 5
  • Genotype 6

Sofosbuvir and ribavirin (without interferon) for adults with:

  • Genotype 1
  • Genotype 4
  • Genotype 5
  • Genotype 6

Sofosbuvir will also not be available on the NHS to people with:

  • Genotype 2 who have not tried treatment before and are able to take interferon
  • Genotype 3 who have not tried treatment before and do not have cirrhosis