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Duration of treatment and ribavirin dosage

The current standard treatment course for pegylated interferon and ribavirin is:

  • 24 weeks for genotypes 2 and 3 with 800 mg of ribavirin daily
  • 48 weeks for all other genotypes with 1000-1200 mg of ribavirin daily

It is worth noting that ribavirin doses may be adjusted depending on the weight of the patient and blood test results. It is best to speak to your consultant if you have concerns over your medications

The trial that produced these results (Hadziyannis et al. 2004) compared genotype 1 against all other genotypes. However, since genotypes 4, 5 & 6 are much less common in the published data below genotype non-1 refers to types 2 or 3.

Pegylated interferon and ribavirin

Percentage with SVR or sustained virological response (no detectable

virus 6 months after the end of treatment)

Treatment duration

Genotype 1

Genotype non-1

24 weeks (800mg ribavirin)

29%

78%

24 weeks (1000/1200mg ribavirin)

41%

78%

48 weeks (800mg ribavirin)

40%

73%

48 weeks (1000/1200mg ribavirin)

51%

77%